Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 2/20 | 0.51 |
| ▸ | ARG2 | P78540 | 1/20 | 0.51 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | ODC1 | P11926 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SPTLC1 | O15269 | 1/20 | 0.31 |
| ▸ | SPTLC2 | O15270 | 1/20 | 0.31 |
| ▸ | GGT1 | P19440 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8519727 | 0.79 | ARG1 (0.33) | ARG1ARG2 | |
| SCHEMBL5014848 | 0.79 | ARG1 (0.46) | ARG1ARG2NOS3NOS1NOS2 | |
| SCHEMBL9905565 | 0.78 | ARG1 (0.33) | ARG1ARG2ODC1KDM4ELMNA | |
| SCHEMBL1097800 | 0.77 | ARG1 (0.56) | ARG1ARG2NOS3NOS1NOS2 | |
| SCHEMBL9568397 | 0.77 | ARG1 (0.56) | ARG1ARG2NOS3NOS1NOS2 | |
| SCHEMBL1915583 | 0.77 | ARG1 (0.32) | ARG1ARG2ODC1KDM4ELMNA | |
| SCHEMBL9005591 | 0.75 | ARG1 (0.55) | ARG1ARG2NOS3NOS1NOS2 | |
| SCHEMBL28218941 | 0.73 | ODC1 (0.66) | ARG1ARG2NOS3NOS1NOS2 | |
| SCHEMBL1915859 | 0.73 | ARG1 (0.37) | ARG1ARG2NOS3NOS1NOS2 | |
| SCHEMBL14689712 | 0.73 | ARG1 (0.62) | ARG1ARG2NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |