Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5013447 | 0.73 | PNKP (0.41) | LMNATACR1KMT2AGNRHRGAA | |
| SCHEMBL1086032 | 0.71 | ALDH1A1 (0.41) | ALDH1A1LMNAKCNJ1TACR1SMN1; SMN2 | |
| SCHEMBL1086535 | 0.65 | KCNJ1 (0.47) | ALDH1A1LMNAKCNJ1TACR1SMN1; SMN2 | |
| SCHEMBL1086474 | 0.64 | ALDH1A1 (0.44) | ALDH1A1LMNAKCNJ1TACR1SMN1; SMN2 | |
| SCHEMBL8973475 | 0.63 | TDP1 (0.62) | ALDH1A1LMNASMN1; SMN2HPGDPOLB | |
| SCHEMBL7563807 | 0.62 | ALDH1A1 (0.61) | ALDH1A1LMNAKCNJ1TACR1SMN1; SMN2 | |
| SCHEMBL1086475 | 0.62 | ALDH1A1 (0.48) | ALDH1A1LMNAKCNJ1TACR1SMN1; SMN2 | |
| SCHEMBL8973826 | 0.62 | TDP1 (0.57) | ALDH1A1LMNASMN1; SMN2HPGDMAPT | |
| SCHEMBL1578893 | 0.61 | KMT2A (0.50) | ALDH1A1LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL922716 | 0.61 | KCNJ1 (0.74) | ALDH1A1LMNAKCNJ1TACR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |