Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNKP | Q96T60 | 3/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.34 |
| ▸ | GNRHR | P30968 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4262148 | 0.77 | PNKP (0.39) | PNKPTACR1MEN1KMT2AEDNRA | |
| SCHEMBL5015167 | 0.73 | ALDH1A1 (0.40) | TACR1MEN1KMT2AGAAGNRHR | |
| SCHEMBL18375356 | 0.63 | ALDH1A1 (0.46) | MEN1KMT2ATRPV1GAALMNA | |
| SCHEMBL29408478 | 0.63 | ALDH1A1 (0.46) | MEN1KMT2ATRPV1GAALMNA | |
| SCHEMBL7932004 | 0.63 | MEN1 (0.51) | MEN1KMT2A | |
| SCHEMBL7763963 | 0.63 | PDE4A (0.40) | MEN1KMT2AEDNRA | |
| SCHEMBL7767275 | 0.63 | PDE4A (0.40) | MEN1KMT2AEDNRA | |
| SCHEMBL7995664 | 0.62 | PDE4B (0.41) | MEN1KMT2AROCK2ROCK1 | |
| SCHEMBL8007232 | 0.62 | PDE4B (0.41) | MEN1KMT2AROCK2ROCK1 | |
| SCHEMBL7765376 | 0.62 | EDNRA (0.41) | MEN1KMT2AEDNRAROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |