⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1006789 | 1.00 | — | — | |
| SCHEMBL199551 | 1.00 | — | — | |
| SCHEMBL15168974 | 1.00 | — | — | |
| SCHEMBL199118 | 0.95 | THRB (0.41) | — | |
| SCHEMBL198579 | 0.95 | THRB (0.41) | — | |
| SCHEMBL1564813 | 0.95 | THRB (0.41) | — | |
| SCHEMBL199064 | 0.95 | THRB (0.41) | — | |
| SCHEMBL199052 | 0.95 | THRB (0.41) | — | |
| SCHEMBL6866130 | 0.85 | — | — | |
| SCHEMBL13515822 | 0.76 | ADH1A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3146050-B1 | INHIBITING OR DOWNREGULATING GLYCOGEN SYNTHASE BY CREATING PREMATURE STOP CODONS USING ANTISENSE OLIGONUCLEOTIDES | GENZYME CORP (US) | 2020-08-12 | — | — | EP | disclosed |
| US-20170182189-A1 | INHIBITING OR DOWNREGULATING GLYCOGEN SYNTHASE BY CREATING PREMATURE STOP CODONS USING ANTISENSE OLIGONUCLEOTIDES | GENZYME CORPORATION | 2017-06-29 | — | — | US | disclosed |
| EP-3146050-A1 | INHIBITING OR DOWNREGULATING GLYCOGEN SYNTHASE BY CREATING PREMATURE STOP CODONS USING ANTISENSE OLIGONUCLEOTIDES | Genzyme Corporation (US) | 2017-03-29 | — | — | EP | disclosed |
| WO-2015179743-A1 | LIBRARY AND SCREENING APPROACH FOR IMPROVED CELL PENETRATING PEPTIDES | GENZYME CORPORATION (US) | 2015-11-26 | — | — | WO | disclosed |
| WO-2015179741-A1 | INHIBITING OR DOWNREGULATING GLYCOGEN SYNTHASE BY CREATING PREMATURE STOP CODONS USING ANTISENSE OLIGONUCLEOTIDES | GENZYME CORPORATION (US) | 2015-11-26 | — | — | WO | disclosed |
| EP-1513871-B1 | PYRROLIDINYL PEPTIDE NUCLEIC ACIDS | ISIS INNOVATION (GB) | 2008-10-29 | — | — | EP | disclosed |
| US-7098321-B2 | Homologous peptide nucleic acids | ISIS INNOVATION LIMITED (GB) | 2006-08-29 | — | — | US | disclosed |
| US-20030228588-A1 | Homologous peptide nucleic acids | ISIS INNOVATION LIMITED | 2003-12-11 | — | — | US | disclosed |
| US-20030157500-A1 | Pyrrolidinyl peptide nucleic acids | ISIS INNOVATION LIMITED (GB) | 2003-08-21 | — | — | US | disclosed |