Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 14/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5016462 | 0.90 | HSD11B1 (0.44) | HSD11B1GAAJAK3 | |
| SCHEMBL1605164 | 0.86 | HSD11B1 (0.34) | HSD11B1GAA | |
| SCHEMBL1605602 | 0.85 | HSD11B1 (0.33) | HSD11B1MEN1KMT2A | |
| SCHEMBL5065069 | 0.73 | HSD11B1 (0.40) | HSD11B1KMT2A | |
| SCHEMBL5016864 | 0.73 | HSD11B1 (0.40) | HSD11B1KMT2A | |
| SCHEMBL5016418 | 0.73 | HSD11B1 (0.40) | HSD11B1KMT2A | |
| SCHEMBL1605628 | 0.73 | HSD11B1 (0.40) | HSD11B1KMT2A | |
| SCHEMBL5630610 | 0.73 | HSD11B1 (0.40) | HSD11B1KMT2A | |
| SCHEMBL1605493 | 0.73 | MEN1 (0.33) | GAAJAK3MEN1KMT2A | |
| SCHEMBL1605435 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753736-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | AMGEN INC (US) | 2008-12-17 | — | — | EP | disclosed |