Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015319 | 0.90 | HSD11B1 (0.43) | HSD11B1GAAJAK3 | |
| SCHEMBL1605164 | 0.88 | HSD11B1 (0.34) | HSD11B1GAA | |
| SCHEMBL1605602 | 0.84 | HSD11B1 (0.33) | HSD11B1 | |
| SCHEMBL21067297 | 0.74 | HSD11B1 (0.42) | HSD11B1 | |
| SCHEMBL5025303 | 0.74 | HSD11B1 (0.42) | HSD11B1 | |
| SCHEMBL1605949 | 0.74 | HSD11B1 (0.42) | HSD11B1 | |
| SCHEMBL5138688 | 0.74 | HSD11B1 (0.42) | HSD11B1 | |
| SCHEMBL5016463 | 0.72 | HSD11B1 (0.44) | HSD11B1 | |
| SCHEMBL1605493 | 0.70 | MEN1 (0.33) | GAAJAK3 | |
| SCHEMBL10249545 | 0.69 | HSD11B1 (0.41) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753736-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | AMGEN INC (US) | 2008-12-17 | — | — | EP | disclosed |
| US-7253196-B2 | Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 | AMGEN, INC. (US) | 2007-08-07 | — | — | US | disclosed |