Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015727 | 0.86 | DPP4 (0.50) | KDM4EKMT2AMEN1PDCD1LG2CD274 | |
| SCHEMBL5025721 | 0.84 | MAOB (0.37) | LMNAKDM4EKMT2AMEN1HPGD | |
| SCHEMBL5024195 | 0.83 | MAOB (0.47) | LMNAKDM4EKMT2AMEN1PDCD1LG2 | |
| SCHEMBL5024304 | 0.82 | DPP4 (0.44) | KDM4EKMT2AMEN1PDCD1LG2CD274 | |
| SCHEMBL5015646 | 0.81 | KDM4E (0.47) | LMNAKDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL5017745 | 0.81 | MAOB (0.36) | KDM4EKMT2AMEN1PDCD1LG2CD274 | |
| SCHEMBL5017586 | 0.80 | MAOB (0.41) | KMT2AMEN1PDCD1LG2CD274POLB | |
| SCHEMBL5017759 | 0.80 | MAOB (0.37) | LMNAKDM4EHPGDPOLBMAPT | |
| SCHEMBL5025797 | 0.78 | ALDH1A1 (0.36) | LMNAKDM4ECA12CA1CA2 | |
| SCHEMBL5024152 | 0.74 | POLB (0.34) | LMNAKMT2AMEN1PDCD1LG2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904449-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007008502-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-01-18 | — | — | WO | disclosed |