Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | POLB | P06746 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA3 | P07451 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5024158 | 0.79 | TP53 (0.41) | KDM4EHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL5025775 | 0.72 | HSD17B1 (0.45) | KDM4EALDH1A1POLBHSD17B10SMN1; SMN2 | |
| SCHEMBL28018438 | 0.69 | KDM4E (0.59) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL24895093 | 0.66 | LMNA (0.55) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL10390929 | 0.66 | LMNA (0.59) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL26965977 | 0.66 | KDM4E (0.81) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL16832123 | 0.66 | KDM4E (0.58) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL21070811 | 0.65 | LMNA (0.54) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL5009698 | 0.65 | KDM4E (0.54) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL15129579 | 0.64 | KDM4E (0.73) | KDM4EALDH1A1POLBHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904449-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007008502-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-01-18 | — | — | WO | disclosed |