SCHEMBL501581

SCHEMBL501581

CC1(C)CCC(C)(C)c2cc(-c3ccc(-c4ccc(O)c(=O)cc4)cc3)ccc21

nearest known ligand 0.60

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
RARB P10826 15/20 0.60
RARA P10276 14/20 0.60
RARG P13631 14/20 0.60
RXRA P19793 5/20 0.50
TP53 P04637 1/20 0.42
CYP1A2 P05177 1/20 0.42
ABCB1 P08183 1/20 0.42
ABCC1 P33527 1/20 0.42
RXRB P28702 1/20 0.42
RXRG P48443 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14425203 1.00 RARB (0.60) RARBRARARARGRXRATP53
SCHEMBL14425251 0.86 RARB (0.63) RARBRARARARGRXRATP53
SCHEMBL14425208 0.86 RARB (0.47) RARBRARARARGRXRATP53
SCHEMBL5847673 0.81 RARB (0.58) RARBRARARARGRXRAABCB1
SCHEMBL14425248 0.80 KDM4E (0.50) RARBRARARARGRXRATP53
SCHEMBL14425212 0.80 RARG (0.47) RARBRARARARGRXRATP53
SCHEMBL14425205 0.80 RXRA (0.63) RARBRARARARGRXRATP53
SCHEMBL14425241 0.80 CYP26B1 (0.53) RARBRARARARGRXRATP53
SCHEMBL14425243 0.80 RARB (0.63) RARBRARARARGRXRATP53
SCHEMBL5846435 0.79 RARA (0.55) RARBRARARARGRXRATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090291492-A1 METHOD FOR FORMING ORGAN RESEARCH FOUNDATION ITSUU LABORATORY (JP) 2009-11-26 US claimed
US-20070161105-A1 Method of forming organ REASEARCH FOUNDATION ITSUU LABORATORY (JP) 2007-07-12 US claimed
EP-1612264-A1 ORGAN-FORMING METHOD Research Foundation Itsuu Laboratory (JP) 2006-01-04 EP claimed
US-8105833-B2 Method for forming organ RESEARCH FOUNDATION ITSUU LABORATORY (JP) 2012-01-31 US disclosed
US-20090291492-A1 METHOD FOR FORMING ORGAN RESEARCH FOUNDATION ITSUU LABORATORY (JP) 2009-11-26 US disclosed
US-20070161105-A1 Method of forming organ REASEARCH FOUNDATION ITSUU LABORATORY (JP) 2007-07-12 US disclosed
EP-1612264-A1 ORGAN-FORMING METHOD Research Foundation Itsuu Laboratory (JP) 2006-01-04 EP disclosed