Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.82 |
| ▸ | ATM | Q13315 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | HPGD | P15428 | 5/20 | 0.65 |
| ▸ | GAA | P10253 | 4/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.64 |
| ▸ | GLA | P06280 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5013137 | 0.92 | KDM4E (0.85) | KDM4ETDP1ATMALDH1A1HPGD | |
| SCHEMBL5014738 | 0.91 | KDM4E (0.83) | KDM4ETDP1ATMALDH1A1HPGD | |
| SCHEMBL4045544 | 0.90 | KDM4E (0.82) | KDM4ETDP1ATMALDH1A1HPGD | |
| SCHEMBL426279 | 0.90 | KDM4E (1.00) | KDM4ETDP1ATMALDH1A1HPGD | |
| SCHEMBL4045460 | 0.83 | KDM4E (0.59) | KDM4ETDP1ATMALDH1A1HPGD | |
| SCHEMBL14955316 | 0.82 | KDM4E (0.85) | KDM4ETDP1ATMALDH1A1HPGD | |
| SCHEMBL425244 | 0.80 | ALDH1A1 (0.91) | KDM4ETDP1ATMALDH1A1HPGD | |
| SCHEMBL5015905 | 0.78 | KDM4E (0.64) | KDM4ETDP1ATMALDH1A1HPGD | |
| SCHEMBL4054324 | 0.78 | KDM4E (0.69) | KDM4ETDP1ATMALDH1A1HPGD | |
| SCHEMBL429219 | 0.75 | KDM4E (0.74) | KDM4ETDP1ATMALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207645-A1 | Pyridothienopyrimidine Derivatives | PAGES SANTACANA LUIS MIGUEL | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207645-A1 | Pyridothienopyrimidine Derivatives | PDE4A, PDE5A, PDE3B | KDM4E 1526/4885TDP1 105/4885ATM 2846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.