Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2783445 | 0.85 | TSHR (0.49) | NOTUMALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL553450 | 0.82 | HDAC1 (0.42) | NOTUMALDH1A1PRMT5WDR77MEN1 | |
| SCHEMBL30195056 | 0.82 | HDAC1 (0.42) | NOTUMALDH1A1PRMT5WDR77MEN1 | |
| SCHEMBL20597169 | 0.81 | NOTUM (0.40) | NOTUMALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL17802218 | 0.79 | ALDH1A1 (0.43) | NOTUMALDH1A1PRMT5WDR77MEN1 | |
| SCHEMBL5015055 | 0.77 | POLB (0.48) | ALDH1A1MEN1KMT2ALMNATSHR | |
| SCHEMBL23293671 | 0.77 | PTGER4 (0.54) | MEN1KMT2A | |
| SCHEMBL6646141 | 0.77 | L3MBTL1 (0.43) | ALDH1A1PRMT5WDR77MEN1KMT2A | |
| SCHEMBL17802204 | 0.76 | PRMT5 (0.38) | NOTUMALDH1A1PRMT5WDR77MEN1 | |
| SCHEMBL4666060 | 0.73 | NOTUM (0.43) | NOTUMALDH1A1PRMT5WDR77MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896014-A2 | CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-03-12 | — | — | EP | disclosed |
| EP-1793826-A2 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-06-13 | — | — | EP | disclosed |
| WO-2007005534-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-01-11 | — | — | WO | disclosed |
| EP-1703905-A1 | INDOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS IN PARTICULAR IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-09-27 | — | — | EP | disclosed |
| WO-2006034317-A2 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-03-30 | — | — | WO | disclosed |
| WO-2005067923-A1 | INDOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS IN PARTICULAR IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-28 | — | — | WO | disclosed |