Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.48 |
| ▸ | HRH1 | P35367 | 8/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012719 | 0.97 | HRH1 (0.49) | HRH3HRH1KCNH2ADRA1BADRA1A | |
| SCHEMBL5013338 | 0.96 | HRH1 (0.48) | HRH3HRH1KCNH2ADRA1BADRA1A | |
| SCHEMBL5011646 | 0.96 | HRH1 (0.48) | HRH3HRH1KCNH2ADRA1BADRA1A | |
| SCHEMBL5011767 | 0.94 | HRH3 (0.45) | HRH3HRH1KCNH2ADRA1BADRA1A | |
| SCHEMBL2097825 | 0.86 | GRM2 (0.36) | GRM2DRD2 | |
| SCHEMBL2095271 | 0.85 | CHRM4 (0.37) | HRH3HRH1KCNH2ADRA1BADRA1A | |
| SCHEMBL2097327 | 0.84 | CHRM4 (0.36) | HRH3HRH1KCNH2ADRA1BADRA1A | |
| SCHEMBL2096496 | 0.84 | CHRM4 (0.36) | HRH3HRH1KCNH2ADRA1BADRA1A | |
| SCHEMBL2094923 | 0.84 | GRM2 (0.37) | GRM2DRD2 | |
| SCHEMBL5011693 | 0.81 | ADRA1A (0.45) | HRH3HRH1KCNH2ADRA1BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |