Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 12/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011767 | 0.87 | HRH3 (0.45) | ADRA1AADRA1BADRA1DHTR1ADRD2 | |
| SCHEMBL2095907 | 0.84 | MAOB (0.44) | HRH3 | |
| SCHEMBL5016310 | 0.81 | HRH3 (0.48) | ADRA1AADRA1BHTR1AHTR2CDRD2 | |
| SCHEMBL5012719 | 0.81 | HRH1 (0.49) | ADRA1AADRA1BHTR1AHTR2CDRD2 | |
| SCHEMBL27644453 | 0.80 | SIGMAR1 (0.47) | ADRA1AADRA1BADRA1DALDH1A1CYP1A2 | |
| SCHEMBL5011646 | 0.80 | HRH1 (0.48) | ADRA1AADRA1BHTR1AHTR2CDRD2 | |
| SCHEMBL5013338 | 0.80 | HRH1 (0.48) | ADRA1AADRA1BHTR1AHTR2CDRD2 | |
| SCHEMBL5012696 | 0.76 | SIGMAR1 (0.46) | ADRA1AADRA1BADRA1DHTR1AHTR2C | |
| SCHEMBL5013459 | 0.73 | MEN1 (0.52) | ADRA1AADRA1BADRA1DALDH1A1HTR1A | |
| SCHEMBL5013346 | 0.73 | KDM4E (0.45) | ALDH1A1MAPTTSHRMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |