Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 5/20 | 0.48 |
| ▸ | IGF1R | P08069 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD1 | P21728 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD5 | P21918 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10740386 | 0.77 | LMNA (0.34) | MAPTPTGS1LMNA | |
| SCHEMBL7362771 | 0.75 | BACE1 (0.48) | BACE1CYP2D6TAAR1CYP1A2NFKB1 | |
| SCHEMBL30631592 | 0.75 | ALOX15 (0.80) | ALOX15IGF1RMAPTKDM4EALDH1A1 | |
| SCHEMBL107956 | 0.75 | ALOX15 (0.80) | ALOX15IGF1RMAPTKDM4EALDH1A1 | |
| SCHEMBL10736157 | 0.74 | CYP1A2 (0.41) | TAAR1CYP1A2 | |
| SCHEMBL3151668 | 0.74 | GFER (0.52) | MAPTALDH1A1GAARECQLTDP1 | |
| SCHEMBL224352 | 0.74 | DAO (0.41) | ALDH1A1MAPK1HSD17B10TAAR1LMNA | |
| SCHEMBL8431254 | 0.73 | ALOX15 (0.76) | ALOX15IGF1RMAPTKDM4EALDH1A1 | |
| SCHEMBL1753940 | 0.73 | KCNH2 (0.50) | ALOX15ALDH1A1BACE1TDP1HSD17B10 | |
| SCHEMBL222600 | 0.72 | TAAR1 (0.47) | RECQLCYP2D6TAAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753736-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | AMGEN INC (US) | 2008-12-17 | — | — | EP | disclosed |