Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515427 | 0.89 | — | — | |
| SCHEMBL1515559 | 0.89 | — | — | |
| SCHEMBL174248 | 0.89 | — | — | |
| SCHEMBL10321391 | 0.80 | ALDH1A1 (0.39) | ALDH1A1TDP1 | |
| SCHEMBL28478737 | 0.79 | FAAH (0.33) | ALDH1A1FAAH | |
| SCHEMBL21326732 | 0.77 | ALDH1A1 (0.61) | ALDH1A1TDP1 | |
| SCHEMBL17135341 | 0.76 | LPAR2 (0.42) | ALDH1A1 | |
| Pyrrole SCHEMBL7517518 | 0.75 | ALDH1A1 (0.35) | ALDH1A1TDP1 | |
| Acetone SCHEMBL28328874 | 0.75 | ALDH1A1 (0.47) | ALDH1A1ABCC4MAPT | |
| SCHEMBL1496213 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007030849-A1 | METHOD FOR DETECTING ORGANIC COMPOUNDS | Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung (AT) | 2007-03-22 | — | — | WO | claimed |
| EP-1738397-A2 | TARGET FOR LASER DESORPTION/IONISATION MASS SPECTROMETRY | Physikalisches Büro Steinmüller GmbH (AT) | 2007-01-03 | — | — | EP | claimed |
| WO-2005096346-A2 | TARGET FOR LASER DESORPTION/IONISATION MASS SPECTROMETRY | PHYSIKALISCHES BÜRO STEINMÜLLER GMBH (AT) | 2005-10-13 | — | — | WO | claimed |
| US-8105513-B2 | Pipette tip containing particle-filled polymer monolith | BONN ALEXANDER (AT) | 2012-01-31 | — | — | US | disclosed |
| US-20100009845-A1 | Pipette Tip Containing Particle-Filled Polymer Monolith | BONN ALEXANDER | 2010-01-14 | — | — | US | disclosed |
| WO-2007030849-A1 | METHOD FOR DETECTING ORGANIC COMPOUNDS | Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung (AT) | 2007-03-22 | — | — | WO | disclosed |
| EP-1738397-A2 | TARGET FOR LASER DESORPTION/IONISATION MASS SPECTROMETRY | Physikalisches Büro Steinmüller GmbH (AT) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005096346-A2 | TARGET FOR LASER DESORPTION/IONISATION MASS SPECTROMETRY | PHYSIKALISCHES BÜRO STEINMÜLLER GMBH (AT) | 2005-10-13 | — | — | WO | disclosed |