Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | YES1 | P07947 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1401690 | 0.87 | KDR (0.59) | KDRPDGFRBRETCHEK2PLK4 | |
| SCHEMBL5015549 | 0.87 | KDR (0.51) | KDRPDGFRBRETCHEK2PLK4 | |
| SCHEMBL5017339 | 0.85 | CHEK2 (0.44) | CHEK2CSF1RDNMT3ANSD2GPR119 | |
| SCHEMBL5015572 | 0.84 | KDR (0.53) | KDRPDGFRBRETCHEK2PLK4 | |
| SCHEMBL5016826 | 0.82 | PDE10A (0.45) | CHEK2DNMT3ANSD2GPR119EHMT2 | |
| SCHEMBL5025614 | 0.79 | KDR (0.54) | KDRPDGFRBRETCHEK2PLK4 | |
| SCHEMBL5025618 | 0.79 | KDR (0.54) | KDRPDGFRBRETCHEK2PLK4 | |
| SCHEMBL5016778 | 0.78 | NSD2 (0.49) | KDRABL1ERBB2SRCABL2 | |
| SCHEMBL662774 | 0.78 | KDR (0.57) | KDRPDGFRBRETCHEK2PLK4 | |
| SCHEMBL29111046 | 0.78 | PDGFRA (0.43) | KDRPDGFRBCHEK2EGFRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309587-B1 | CINNOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | EP | disclosed |
| EP-1309587-B1 | CINNOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | EP | disclosed |
| US-6887874-B2 | Cinnoline compounds | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| US-20030212055-A1 | Cinnoline compounds | ASTRAZENECA AB (SE) | 2003-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212055-A1 | Cinnoline compounds | VEGFA, PGF, CCR7 | KDR 12/4885PDGFRB 514/4885RET 2774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.