SCHEMBL5017642

SCHEMBL5017642

O=C(C1CC1)N(C(=S)Nc1ccc(Oc2ccnc3ccsc23)c(F)c1)c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MET P08581 20/20 0.62
KDR P35968 14/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5017641 0.79 MET (0.60) METKDR
SCHEMBL307620 0.77 MET (1.00) METKDR
SCHEMBL2282742 0.75 MET (1.00) METKDR
SCHEMBL3562834 0.75 MET (0.70) METKDR
SCHEMBL12376534 0.74 MET (1.00) METKDR
SCHEMBL2280846 0.74 MET (0.71) METKDR
SCHEMBL3565894 0.74 MET (0.71) METKDR
SCHEMBL3563912 0.74 MET (0.84) METKDR
SCHEMBL2289171 0.74 MET (0.72) METKDR
SCHEMBL2281349 0.73 MET (0.77) METKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1904504-A2 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING Methylgene, Inc. (CA) 2008-04-02 EP disclosed
WO-2007054831-A2 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING METHYLGENE, INC. (CA) 2007-05-18 WO disclosed