Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.60 |
| ▸ | KDR | P35968 | 13/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5017642 | 0.79 | MET (0.62) | METKDR | |
| SCHEMBL307620 | 0.75 | MET (1.00) | METKDR | |
| SCHEMBL2280846 | 0.74 | MET (0.71) | METKDR | |
| SCHEMBL2289171 | 0.74 | MET (0.72) | METKDR | |
| SCHEMBL2282742 | 0.73 | MET (1.00) | METKDR | |
| SCHEMBL5017643 | 0.73 | MET (0.56) | METKDR | |
| SCHEMBL3562834 | 0.73 | MET (0.70) | METKDR | |
| SCHEMBL2281349 | 0.73 | MET (0.77) | METKDR | |
| SCHEMBL12376534 | 0.73 | MET (1.00) | METKDR | |
| SCHEMBL2284919 | 0.73 | MET (0.87) | METKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904504-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | Methylgene, Inc. (CA) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007054831-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE, INC. (CA) | 2007-05-18 | — | — | WO | disclosed |