Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CXCL8 | P10145 | 5/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8012913 | 0.81 | PTGER3 (0.61) | AKR1B1TDP1PTGER4PTGER3PTGER2 | |
| SCHEMBL8012911 | 0.81 | PTGER3 (0.61) | AKR1B1TDP1PTGER4PTGER3PTGER2 | |
| SCHEMBL5026445 | 0.80 | KDM4E (0.42) | TDP1PTGER4PTGER3PTGER2KDM4E | |
| SCHEMBL115054 | 0.79 | SRC (0.58) | AKR1B1TDP1CXCL8BCAT2SRC | |
| SCHEMBL28314097 | 0.77 | MAPT (0.54) | AKR1B1PTGER4PTGER3PTGER2KDM4E | |
| SCHEMBL156765 | 0.77 | AKR1B1 (0.55) | AKR1B1TDP1CXCL8BCAT2SRC | |
| SCHEMBL5027822 | 0.76 | PTGER4 (0.33) | PTGER4PTGER3PTGER2 | |
| Hydrochloric Acid SCHEMBL10627468 | 0.76 | AKR1B1 (0.53) | AKR1B1TDP1CXCL8BCAT2SRC | |
| Lithium SCHEMBL29604103 | 0.76 | AKR1B1 (0.53) | AKR1B1TDP1CXCL8BCAT2SRC | |
| SCHEMBL27976060 | 0.76 | AKR1B1 (0.53) | AKR1B1TDP1CXCL8BCAT2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904504-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | Methylgene, Inc. (CA) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007054831-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE, INC. (CA) | 2007-05-18 | — | — | WO | disclosed |