Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 1/20 | 0.36 |
| ▸ | TFEB | P19484 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26075997 | 0.85 | KDM4E (0.43) | KDM4ENFE2L2TSHRPTGER4PTGER3 | |
| SCHEMBL9775462 | 0.83 | TRPA1 (0.47) | KDM4ENFE2L2PTGER4PTGER3PTGER2 | |
| SCHEMBL9775463 | 0.83 | TRPA1 (0.47) | KDM4ENFE2L2PTGER4PTGER3PTGER2 | |
| SCHEMBL4893812 | 0.81 | ALDH1A1 (0.44) | KDM4ENFE2L2TSHRCYP4F2CYP4A11 | |
| SCHEMBL9011882 | 0.80 | ALDH1A1 (0.43) | KDM4ENFE2L2TSHRCYP4F2CYP4A11 | |
| SCHEMBL5283277 | 0.80 | KDM4E (0.43) | KDM4ENFE2L2TSHRCYP4F2CYP4A11 | |
| SCHEMBL5017809 | 0.80 | AKR1B1 (0.52) | KDM4EPTGER4PTGER3PTGER2MAPT | |
| SCHEMBL22945868 | 0.79 | KDM4E (0.39) | KDM4ENFE2L2TSHRPTGER4PTGER3 | |
| SCHEMBL1554320 | 0.78 | KDM4E (0.53) | KDM4ETSHRCYP4F2CYP4A11EGFR | |
| SCHEMBL9016430 | 0.77 | USP2 (0.47) | KDM4ETSHREGFRSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904504-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | Methylgene, Inc. (CA) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007054831-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE, INC. (CA) | 2007-05-18 | — | — | WO | disclosed |