SCHEMBL8012913

SCHEMBL8012913

O=C(O)C=Cc1ccccc1CC(=O)O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER3 P43115 11/20 0.61
PTGER2 P43116 10/20 0.61
PTGER4 P35408 8/20 0.61
CA1 P00915 1/20 0.56
CA2 P00918 1/20 0.56
NFKB1 P19838 1/20 0.56
CA4 P22748 1/20 0.56
PTGDR Q13258 5/20 0.55
TBXA2R P21731 4/20 0.55
PTGFR P43088 3/20 0.55
PTGER1 P34995 4/20 0.54
PTGIR P43119 2/20 0.54
AKR1B1 P15121 1/20 0.52
TBXAS1 P24557 1/20 0.51
HTT P42858 1/20 0.49
MAPT P10636 1/20 0.49
HDAC3 O15379 1/20 0.48
TNKS O95271 1/20 0.48
HDAC4 P56524 1/20 0.48
HDAC1 Q13547 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8012911 1.00 PTGER3 (0.61) PTGER3PTGER2PTGER4CA1CA2
SCHEMBL28314097 0.84 MAPT (0.54) PTGER3PTGER2PTGER4NFKB1AKR1B1
SCHEMBL1150939 0.83 PTGER3 (0.63) PTGER3PTGER2PTGER4CA1CA2
SCHEMBL309761 0.83 PTGER3 (0.63) PTGER3PTGER2PTGER4CA1CA2
SCHEMBL6274118 0.83 PTGER3 (0.63) PTGER3PTGER2PTGER4CA1CA2
SCHEMBL3214322 0.83 PTGER3 (0.63) PTGER3PTGER2PTGER4CA1CA2
SCHEMBL6274122 0.83 PTGER3 (0.63) PTGER3PTGER2PTGER4CA1CA2
SCHEMBL9504322 0.83 PTGER3 (0.55) PTGER3PTGER2PTGER4CA1CA2
SCHEMBL3557041 0.81 PTGER3 (0.61) PTGER3PTGER2PTGER4CA1CA2
SCHEMBL8105303 0.81 PTGER3 (0.61) PTGER3PTGER2PTGER4CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6100264-A 5H, 10H-imidazo [1,2-A] indeno [1,2-E] pyrazin-4-one derivatives, their preparation, their intermediates and medicaments containing them RHONE-POULENC RORER, S.A. (FR) 2000-08-08 US disclosed
US-6057454-A USEFUL FOR TREATING OR PREVENTING ALL ISCHAEMIAS (SUCH AS FOCAL OR GLOBAL ISCHAEMIA) RESULTING FROM CEREBROVASCULAR DISORDERS RHONE-POULENC RORER S.A. (FR) 2000-05-02 US disclosed
US-5990108-A USEFUL AS ANTAGONISTS OF THE ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (AMPA) RECEPTOR, ALSO KNOWN AS THE QUISQUALATE RECEPTOR, AND AS ANTAGONISTS OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR RHONE POULENC RORER S.A. (FR) 1999-11-23 US disclosed
US-5902803-A 5H,10H-imidazo 1,2-a!indeno 1,2-e!pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives RHONE-POULENC RORER S.A. (FR) 1999-05-11 US disclosed