Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 5/20 | 0.57 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.54 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | UBE2M | P61081 | 1/20 | 0.44 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5025229 | 0.87 | PSMB5 (0.52) | PSMB5PSMB1CTNNB1IDO1STAT3 | |
| SCHEMBL5019127 | 0.87 | PSMB5 (0.50) | PSMB5PSMB1CTNNB1IDO1STAT3 | |
| SCHEMBL5019079 | 0.85 | PSMB5 (0.51) | PSMB5PSMB1CTNNB1IDO1STAT3 | |
| SCHEMBL5019029 | 0.84 | PSMB5 (0.47) | PSMB5PSMB1CTNNB1IDO1STAT3 | |
| SCHEMBL5019075 | 0.79 | PSMB5 (0.48) | PSMB5PSMB1CTNNB1IDO1STAT3 | |
| SCHEMBL5018640 | 0.77 | PSMB5 (0.49) | PSMB5PSMB1IDO1STAT3SMN1; SMN2 | |
| SCHEMBL5018524 | 0.77 | PSMB5 (0.49) | PSMB5PSMB1CTNNB1IDO1STAT3 | |
| SCHEMBL5019069 | 0.76 | PSMB5 (0.47) | PSMB5PSMB1CTNNB1IDO1STAT3 | |
| SCHEMBL5019066 | 0.75 | PSMB5 (0.51) | PSMB5PSMB1IDO1STAT3SMN1; SMN2 | |
| SCHEMBL5019067 | 0.75 | ALDH1A1 (0.53) | SMN1; SMN2MEN1KMT2AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178490-B2 | Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof | REMPEX PHARMACEUTICALS, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100152098-A1 | POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | MPEX PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152098-A1 | POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | ABCB11, ABCB1, SLC47A1 | PSMB5 865/4885PSMB1 556/4885CTNNB1 4592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.