Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 2/20 | 0.53 |
| ▸ | KDM1A | O60341 | 11/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 6/20 | 0.43 |
| ▸ | MAOA | P21397 | 5/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23374675 | 1.00 | GRIA4 (0.53) | GRIA4KDM1AADRA2AADRA2BADRA2C | |
| SCHEMBL5019411 | 0.96 | GRIA4 (0.49) | GRIA4KDM1AADRA2AADRA2BADRA2C | |
| SCHEMBL12354245 | 0.96 | GRIA4 (0.49) | GRIA4KDM1AADRA2AADRA2BADRA2C | |
| SCHEMBL25069673 | 0.89 | KDM1A (0.46) | GRIA4KDM1AMAOBMAOAHTR2C | |
| SCHEMBL25069676 | 0.89 | KDM1A (0.46) | GRIA4KDM1AMAOBMAOAHTR2C | |
| SCHEMBL23374693 | 0.79 | KDM1A (0.65) | KDM1AMAOBMAOA | |
| SCHEMBL13076110 | 0.79 | GRIA4 (0.57) | GRIA4KDM1AADRA2AADRA2BADRA2C | |
| SCHEMBL22754979 | 0.79 | GRIA4 (0.57) | GRIA4KDM1AADRA2AADRA2BADRA2C | |
| SCHEMBL13452615 | 0.79 | GRIA4 (0.57) | GRIA4KDM1AADRA2AADRA2BADRA2C | |
| SCHEMBL5019357 | 0.79 | KDM1A (0.65) | KDM1AMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012062750-A1 | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | Janssen Pharmaceuticals, Inc. (US) | 2012-05-18 | — | — | WO | disclosed |