Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GUCY1B2 | O75343 | 3/20 | 0.35 |
| ▸ | GUCY1A2 | P33402 | 3/20 | 0.35 |
| ▸ | GUCY1A1 | Q02108 | 3/20 | 0.35 |
| ▸ | GUCY1B1 | Q02153 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5019548 | 0.96 | NPC1 (0.40) | NPC1PKMRAB9ATERTTGFBR1 | |
| SCHEMBL5019629 | 0.88 | ADORA2A (0.43) | NPC1RAB9ATGFBR1TGFBR2L3MBTL1 | |
| SCHEMBL5019633 | 0.86 | NPC1 (0.43) | NPC1RAB9AL3MBTL1ADORA2AADORA1 | |
| SCHEMBL5019586 | 0.86 | GUCY1B2 (0.39) | TGFBR1TGFBR2L3MBTL1ADORA2AADORA1 | |
| SCHEMBL4562184 | 0.84 | GUCY1B2 (0.38) | TGFBR1TGFBR2ADORA2AADORA1MAPT | |
| SCHEMBL5019576 | 0.84 | MAPT (0.41) | L3MBTL1ADORA2AADORA1MAPTNPSR1 | |
| SCHEMBL5019550 | 0.83 | GUCY1B2 (0.40) | TGFBR1TGFBR2ADORA2AADORA1MAPT | |
| SCHEMBL4561518 | 0.82 | MAPT (0.39) | ADORA2AADORA1MAPTNPSR1GUCY1B2 | |
| SCHEMBL4560653 | 0.82 | GUCY1B2 (0.41) | NPC1RAB9AL3MBTL1ADORA2AADORA1 | |
| SCHEMBL5019647 | 0.81 | ADORA2A (0.46) | PKMTGFBR1TGFBR2L3MBTL1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170112845-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-04-27 | — | — | US | disclosed |
| US-20170112845-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-04-27 | — | — | US | disclosed |
| EP-2637659-B1 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS INC (US) | 2016-05-18 | — | — | EP | disclosed |
| US-20150250795-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-09-10 | — | — | US | disclosed |
| US-20150250795-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-09-10 | — | — | US | disclosed |
| US-9061030-B2 | sGC stimulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-9061030-B2 | sGC stimulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-20140088071-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-03-27 | — | — | US | disclosed |
| US-20140088071-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-03-27 | — | — | US | disclosed |
| WO-2012064559-A1 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150250795-A1 | sGC STIMULATORS | PTGIS, GUCY1B1, GUCY1A1 | NPC1 2967/4885PKM 1082/4885RAB9A 2039/4885 |
| US-20140088071-A1 | sGC STIMULATORS | PTGIS, GUCY1B1, GUCY1A1 | NPC1 3154/4885PKM 1149/4885RAB9A 2122/4885 |
| US-20170112845-A1 | sGC STIMULATORS | PTGIS, GUCY1B1, GUCY1A1 | NPC1 2967/4885PKM 1082/4885RAB9A 2039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.