Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 1/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.42 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.42 |
| ▸ | IL2 | P60568 | 7/20 | 0.40 |
| ▸ | HTR1F | P30939 | 2/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 6/20 | 0.34 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1E | P28566 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5019662 | 0.95 | IL2 (0.40) | STIM1ORAI1ORAI2IL2HTR1F | |
| SCHEMBL5019604 | 0.89 | KMT2A (0.37) | IL2HTR1FMAP3K5CRACR2ANPC1 | |
| SCHEMBL3825366 | 0.86 | IL2 (0.44) | STIM1ORAI1ORAI2IL2HTR1F | |
| SCHEMBL5019760 | 0.84 | IL2 (0.38) | STIM1ORAI1IL2CRACR2ANPC1 | |
| SCHEMBL8186422 | 0.83 | IL2 (0.40) | STIM1ORAI1ORAI2IL2HTR1F | |
| SCHEMBL3824488 | 0.82 | IL2 (0.42) | STIM1ORAI1ORAI2IL2HTR1F | |
| SCHEMBL12650398 | 0.82 | IL2 (0.40) | STIM1ORAI1ORAI2IL2MAP3K5 | |
| SCHEMBL4999197 | 0.82 | IL2 (0.41) | STIM1ORAI1ORAI2IL2HTR1F | |
| SCHEMBL15386459 | 0.80 | IL2 (0.39) | STIM1ORAI1ORAI2IL2HTR1F | |
| SCHEMBL1781053 | 0.79 | CRACR2A (0.40) | STIM1ORAI1IL2CRACR2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |