Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 6/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | CRACR2A | Q9BSW2 | 5/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BMX | P51813 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1781053 | 0.95 | CRACR2A (0.40) | IL2TNFSTIM1ORAI1CRACR2A | |
| SCHEMBL5019598 | 0.89 | IL2 (0.40) | IL2TNFSTIM1ORAI1CHRNA7 | |
| SCHEMBL5019639 | 0.88 | IL2 (0.40) | IL2TNFSTIM1ORAI1CHRNA7 | |
| SCHEMBL987243 | 0.85 | IL2 (0.43) | IL2TNFSTIM1ORAI1CHRNA7 | |
| SCHEMBL5019607 | 0.84 | STIM1 (0.42) | IL2STIM1ORAI1CRACR2ANPC1 | |
| SCHEMBL1782420 | 0.82 | IL2 (0.41) | IL2TNFSTIM1ORAI1CHRNA7 | |
| SCHEMBL1781986 | 0.80 | IL2 (0.46) | IL2JAK1NPC1RAB9A | |
| SCHEMBL5019740 | 0.80 | GAA (0.42) | IL2TNFSTIM1ORAI1C5AR1 | |
| SCHEMBL5019619 | 0.79 | TYK2 (0.45) | IL2JAK1ITGB1ITGA4 | |
| SCHEMBL5019662 | 0.79 | IL2 (0.40) | IL2STIM1ORAI1CRACR2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |