Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | IL2 | P60568 | 1/20 | 0.36 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5019638 | 0.93 | KMT2A (0.41) | AVPR2KMT2AJAK1MAPTTP53 | |
| SCHEMBL1781817 | 0.93 | KMT2A (0.50) | KMT2AJAK1MAPTTP53RAB9A | |
| SCHEMBL5019637 | 0.92 | KMT2A (0.41) | KMT2AJAK1MAPTTP53RAB9A | |
| SCHEMBL987243 | 0.90 | IL2 (0.43) | KMT2AJAK1MAPTTP53RAB9A | |
| SCHEMBL4561040 | 0.89 | KMT2A (0.35) | AVPR2KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL5019599 | 0.88 | SMN1; SMN2 (0.40) | KMT2ATP53RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5019598 | 0.88 | IL2 (0.40) | KMT2AJAK1RAB9ANPC1TNF | |
| SCHEMBL5019716 | 0.86 | RAB9A (0.47) | KMT2AMAPTTP53RAB9ASMN1; SMN2 | |
| SCHEMBL1781784 | 0.86 | SMO (0.44) | KMT2AMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL986998 | 0.85 | STIM1 (0.42) | KMT2ASTIM1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |