Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | SMO | Q99835 | 4/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1781784 | 0.93 | SMO (0.44) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL5019637 | 0.92 | KMT2A (0.41) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL5019619 | 0.88 | TYK2 (0.45) | JAK2 | |
| SCHEMBL5019609 | 0.86 | AVPR2 (0.42) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL5019638 | 0.86 | KMT2A (0.41) | RAB9ANPC1KMT2AMAPTTP53 | |
| SCHEMBL1781817 | 0.86 | KMT2A (0.50) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL1781495 | 0.85 | RAB9A (0.38) | RAB9ANPC1MEN1KMT2AJAK2 | |
| SCHEMBL5019717 | 0.85 | CRACR2A (0.39) | — | |
| SCHEMBL5019754 | 0.84 | GRM5 (0.40) | MEN1KMT2ATP53LMNA | |
| SCHEMBL987243 | 0.83 | IL2 (0.43) | RAB9ANPC1MEN1KMT2AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |