Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 2/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.41 |
| ▸ | CRACR2A | Q9BSW2 | 4/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.40 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.40 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5019611 | 0.91 | RAB9A (0.37) | L3MBTL1KMT2APTPN11 | |
| SCHEMBL986998 | 0.91 | STIM1 (0.42) | STIM1ORAI1CRACR2ACSNK1DCSNK1E | |
| SCHEMBL5019613 | 0.89 | CSNK1D (0.38) | CSNK1DCSNK1EL3MBTL1NR3C1PTPN11 | |
| SCHEMBL1782420 | 0.84 | IL2 (0.41) | STIM1ORAI1KMT2A | |
| SCHEMBL1781495 | 0.84 | RAB9A (0.38) | L3MBTL1KMT2ANR3C1PTPN11 | |
| SCHEMBL1781986 | 0.82 | IL2 (0.46) | — | |
| SCHEMBL5019605 | 0.82 | L3MBTL1 (0.35) | L3MBTL1KMT2APTPN11 | |
| SCHEMBL5019639 | 0.81 | IL2 (0.40) | STIM1ORAI1KMT2ASLC10A1 | |
| SCHEMBL4561040 | 0.80 | KMT2A (0.35) | STIM1ORAI1L3MBTL1KMT2ANR3C1 | |
| SCHEMBL5019765 | 0.80 | CSNK1D (0.37) | CSNK1DCSNK1EL3MBTL1PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |