Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | IL2 | P60568 | 2/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL987243 | 0.92 | IL2 (0.43) | MAPTMEN1KMT2AIL2TNF | |
| SCHEMBL5019598 | 0.90 | IL2 (0.40) | KDM4EMEN1KMT2AIL2TNF | |
| SCHEMBL5019587 | 0.85 | LCLAT1 (0.40) | GAAMAPTGFERTSHRKDM4E | |
| SCHEMBL5019609 | 0.85 | AVPR2 (0.42) | MAPTKDM4EMEN1KMT2ATDP1 | |
| SCHEMBL5019638 | 0.85 | KMT2A (0.41) | MAPTAURKAAURKBKMT2ATDP1 | |
| SCHEMBL1781817 | 0.85 | KMT2A (0.50) | MAPTKDM4EMEN1KMT2ATDP1 | |
| SCHEMBL5019637 | 0.84 | KMT2A (0.41) | MAPTMEN1KMT2ATDP1IL2 | |
| SCHEMBL1782420 | 0.83 | IL2 (0.41) | GAAMAPTMEN1KMT2AIL2 | |
| SCHEMBL5019612 | 0.82 | IL2 (0.40) | GAAMAPTMEN1KMT2AIL2 | |
| SCHEMBL5019639 | 0.82 | IL2 (0.40) | GAAMAPTKMT2AIL2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |