Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5019621 | 0.93 | KDM4E (0.38) | RAB9ANPC1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL5019626 | 0.92 | KDM4E (0.37) | RAB9ANPC1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL5019638 | 0.90 | KMT2A (0.41) | RAB9ANPC1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL5019577 | 0.89 | KDM4E (0.38) | RAB9ANPC1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL5019600 | 0.87 | JAK1 (0.37) | RAB9ANPC1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL5019601 | 0.84 | SMN1; SMN2 (0.37) | RAB9ANPC1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL5019681 | 0.84 | SMN1; SMN2 (0.36) | RAB9ANPC1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL5031237 | 0.83 | AURKA (0.44) | RAB9ANPC1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL5019609 | 0.83 | AVPR2 (0.42) | RAB9ANPC1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL1781817 | 0.83 | KMT2A (0.50) | RAB9ANPC1KDM4ETDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |