Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29993238 | 0.91 | POLB (0.44) | POLBTGM2DRD4SIGMAR1HTR6 | |
| SCHEMBL12944882 | 0.91 | POLB (0.44) | POLBTGM2DRD4SIGMAR1HTR6 | |
| SCHEMBL943113 | 0.91 | POLB (0.44) | POLBTGM2DRD4SIGMAR1HTR6 | |
| SCHEMBL5019942 | 0.91 | POLB (0.44) | POLBTGM2DRD4SIGMAR1HTR6 | |
| SCHEMBL5019960 | 0.88 | TGM2 (0.40) | POLBTGM2DRD4SIGMAR1HTR6 | |
| SCHEMBL19540487 | 0.82 | TGM2 (0.43) | POLBTGM2DRD4SIGMAR1HTR6 | |
| SCHEMBL952698 | 0.82 | POLB (0.42) | POLBTGM2PTGDR2PSEN1PSEN2 | |
| SCHEMBL16791288 | 0.81 | TGM2 (0.42) | POLBTGM2DRD4SIGMAR1HTR6 | |
| SCHEMBL818307 | 0.80 | POLB (0.48) | POLBTGM2DRD4SIGMAR1PTGDR2 | |
| SCHEMBL820580 | 0.80 | POLB (0.48) | POLBTGM2DRD4SIGMAR1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073579-A1 | SMAC Mimetic | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2014-03-13 | — | — | US | disclosed |
| US-20130012564-A1 | SMAC Mimetic | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2013-01-10 | — | — | US | disclosed |
| US-8283372-B2 | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2012-10-09 | — | — | US | disclosed |
| US-20120115922-A1 | SMAC MIMETEC | MEDIVIR AB (SE) | 2012-05-10 | — | — | US | disclosed |
| US-20110003877-A1 | SMAC Mimetic | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012564-A1 | SMAC Mimetic | SMARCC1, SMARCC2, MCL1 | POLB 126/4885TGM2 3272/4885DRD4 4882/4885 |
| US-20110003877-A1 | SMAC Mimetic | SMARCC1, SMARCC2, MCL1 | POLB 126/4885TGM2 3272/4885DRD4 4882/4885 |
| US-20120115922-A1 | SMAC MIMETEC | SMARCC1, SMARCC2, SMARCE1 | POLB 83/4885TGM2 3340/4885DRD4 4877/4885 |
| US-20140073579-A1 | SMAC Mimetic | SMARCC1, SMARCC2, MCL1 | POLB 126/4885TGM2 3272/4885DRD4 4882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.