Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | USP2 | O75604 | 1/20 | 0.73 |
| ▸ | ESR1 | P03372 | 1/20 | 0.73 |
| ▸ | THRB | P10828 | 1/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.73 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.73 |
| ▸ | RECQL | P46063 | 1/20 | 0.73 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.73 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.73 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479457 | 1.00 | HSD17B10 (0.73) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL30520180 | 1.00 | HSD17B10 (0.73) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL7327312 | 1.00 | HSD17B10 (0.73) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL6479462 | 1.00 | HSD17B10 (0.73) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL7348790 | 1.00 | HSD17B10 (0.73) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL10964457 | 0.87 | POLB (0.54) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL10339936 | 0.87 | POLB (0.54) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL7324499 | 0.87 | TDP1 (0.54) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL10636932 | 0.87 | POLB (0.54) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL10339937 | 0.87 | POLB (0.54) | HSD17B10HPGDKDM4EPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 125 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014030106-A2 | PROCESS FOR PREPARATION OF OPTICALLY ACTIVE (2R,3S)-3-(4- METHOXYPHENYL)GLYCIDIC ACID METHYL ESTER AND CIS LACTAM AND USES THEREOF | UNIMARK REMEDIES LTD. (IN) | 2014-02-27 | — | — | WO | claimed |
| EP-0415384-B1 | Heterogeneous synthesis of azepinones from esters | HOECHST MARION ROUSSEL INC (US) | 1997-03-19 | — | — | EP | claimed |
| US-5315005-A | Purification | ZAMBON GROUP S.P.A. (IT) | 1994-05-24 | — | — | US | claimed |
| EP-0325965-B1 | A process for the optical resolution of a racemic acid | PROFARMACO NOBEL SRL (IT) | 1994-04-13 | — | — | EP | claimed |
| EP-0355395-B1 | Process for the preparation of intermediates for the synthesis of diltiazem | ZAMBON SPA (IT) | 1994-03-30 | — | — | EP | claimed |
| US-5223612-A | Process for the preparation of benzothiazepines by cyclization with phosphonic acids | ZAMBON GROUP S.P.A. (IT) | 1993-06-29 | — | — | US | claimed |
| US-5102999-A | Oxidation of cis-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4-one | ZAMBON GROUP S.P.A. (IT) | 1992-04-07 | — | — | US | claimed |
| EP-0242265-B1 | 1,5-BENZOTHIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTICAL USE | SYNTHELABO (FR) | 1991-05-29 | — | — | EP | claimed |
| US-5013835-A | Method of preparing (+)-(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)2,3-dihydro-5H-1,5-benzothiazepine-4-one | SYNTHELABO (FR) | 1991-05-07 | — | — | US | claimed |
| US-5013834-A | Process for the preparation of an optically active benzothiazepinone | INDUSTRIA CHIMICA PROFARMACO S. P. A. (IT) | 1991-05-07 | — | — | US | claimed |
| EP-0415384-A2 | Heterogeneous synthesis of azepinones from esters | HOECHST MARION ROUSSEL, INC. (US) | 1991-03-06 | — | — | EP | claimed |
| US-4937334-A | Process for the preparation of intermediates for the synthesis of diltiazem | ZAMBON GROUP S.P.A. (IT) | 1990-06-26 | — | — | US | claimed |
| EP-0355395-A1 | Process for the preparation of intermediates for the synthesis of diltiazem | ZAMBON GROUP S.p.A. (IT) | 1990-02-28 | — | — | EP | claimed |
| EP-0325965-A2 | A process for the optical resolution of a racemic acid | PROFARMACO NOBEL S.r.l. (IT) | 1989-08-02 | — | — | EP | claimed |
| JP-3048671-A | — | — | None | — | — | JP | disclosed |
| JP-2078673-A | — | — | None | — | — | JP | disclosed |
| JP-5222016-A | — | — | None | — | — | JP | disclosed |
| US-4438035-A | Method of preparing benzothiazepine derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1984-03-20 | — | — | US | disclosed |
| EP-0081234-A1 | Novel method of preparing benzothiazepine derivatives | Tanabe Seiyaku Co., Ltd. (JP) | 1983-06-15 | — | — | EP | disclosed |
| JP-H00348671-A | — | — | 0001-01-01 | — | — | JP | disclosed |