Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | USP2 | O75604 | 1/20 | 0.73 |
| ▸ | ESR1 | P03372 | 1/20 | 0.73 |
| ▸ | THRB | P10828 | 1/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.73 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.73 |
| ▸ | RECQL | P46063 | 1/20 | 0.73 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.73 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.73 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479457 | 1.00 | HSD17B10 (0.73) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL30520180 | 1.00 | HSD17B10 (0.73) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL7327312 | 1.00 | HSD17B10 (0.73) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL5020108 | 1.00 | HSD17B10 (0.73) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL7348790 | 1.00 | HSD17B10 (0.73) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL10964457 | 0.87 | POLB (0.54) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL10339936 | 0.87 | POLB (0.54) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL7324499 | 0.87 | TDP1 (0.54) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL10636932 | 0.87 | POLB (0.54) | HSD17B10HPGDKDM4EPOLBTDP1 | |
| SCHEMBL10339937 | 0.87 | POLB (0.54) | HSD17B10HPGDKDM4EPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430012-B1 | Process for preparing 2-Aromatic-3-halobenzothiazepines | MARION MERRELL DOW INC (US) | 1995-05-10 | — | — | EP | claimed |
| US-5315005-A | Purification | ZAMBON GROUP S.P.A. (IT) | 1994-05-24 | — | — | US | claimed |
| US-5102999-A | Oxidation of cis-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4-one | ZAMBON GROUP S.P.A. (IT) | 1992-04-07 | — | — | US | claimed |
| US-5081240-A | PROCESS FOR THE PREPARATION OF BENZOTHIAZEPIN-ONE DERIVATIVES | SANOFI (FR) | 1992-01-14 | — | — | US | claimed |
| EP-0415384-A2 | Heterogeneous synthesis of azepinones from esters | HOECHST MARION ROUSSEL, INC. (US) | 1991-03-06 | — | — | EP | claimed |
| US-4983733-A | Process for preparing 2-aromatic-3-halobenzothiazepines | MARION LABORATORIES, INC. (US) | 1991-01-08 | — | — | US | claimed |
| JP-61229874-A | — | — | None | — | — | JP | disclosed |
| JP-7002810-A | — | — | None | — | — | JP | disclosed |
| JP-3048671-A | — | — | None | — | — | JP | disclosed |
| JP-3193770-A | — | — | None | — | — | JP | disclosed |
| CN-118291562-A | Preparation method of (2S, 3S) -2, 3-dihydro-3-hydroxy-2-aryl-1, 5-benzothiazepine-4 (5H) -ketone compound | 复旦大学 | 2024-07-05 | — | — | CN | disclosed |
| CN-118290362-A | Process for preparing benzothiazepine isomers | 山东新华制药股份有限公司 | 2024-07-05 | — | — | CN | disclosed |
| US-6881839-B2 | Process for preparing diltiazem using a heterogeneous trifunctional catalyst | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-04-19 | — | — | US | disclosed |
| EP-0158340-B1 | NOVEL 1,5-BENZOTHIAZEPINE DERIVATIVE, PROCESSES FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS | Tanabe Seiyaku Co., Ltd. (JP) | 1989-01-18 | — | — | EP | disclosed |
| JP-S61229874-A | PRODUCTION OF BENZOTHIAZINE DERIVATIVE | TOUBISHI YAKUHIN KOGYO KK | 1986-10-14 | — | — | JP | disclosed |
| US-4566995-A | Process for the preparation of benzothiazepine derivatives | ABIC LTD. (IL) | 1986-01-28 | — | — | US | disclosed |
| US-4521430-A | VASODILATOR, ANTIISCHEMIC AGENT | TANABE SEIYAKU CO., LTD. (JP) | 1985-06-04 | — | — | US | disclosed |
| EP-0128462-A1 | Novel benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions | Tanabe Seiyaku Co., Ltd. (JP) | 1984-12-19 | — | — | EP | disclosed |
| US-4438035-A | Method of preparing benzothiazepine derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1984-03-20 | — | — | US | disclosed |
| EP-0081234-A1 | Novel method of preparing benzothiazepine derivatives | Tanabe Seiyaku Co., Ltd. (JP) | 1983-06-15 | — | — | EP | disclosed |