SCHEMBL5020765

SCHEMBL5020765

CC(=O)/C=C/c1ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 9/20 0.79
MAPT P10636 3/20 0.65
MEN1 O00255 2/20 0.65
ALDH1A1 P00352 2/20 0.65
KMT2A Q03164 2/20 0.65
HDAC8 Q9BY41 7/20 0.64
HDAC3 O15379 4/20 0.64
HDAC11 Q96DB2 4/20 0.64
HDAC6 Q9UBN7 4/20 0.64
UQCRB P14927 1/20 0.62
CYP1A2 P05177 1/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2C19 P33261 1/20 0.58
CA1 P00915 1/20 0.58
CA2 P00918 1/20 0.58
HDAC4 P56524 5/20 0.57
TP53 P04637 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
RORA P35398 1/20 0.56
HDAC7 Q8WUI4 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5020624 0.88 HDAC1 (1.00) HDAC1MAPTHDAC8HDAC3HDAC11
SCHEMBL5020769 0.85 HDAC1 (0.78) HDAC1MAPTMEN1ALDH1A1KMT2A
SCHEMBL5020762 0.84 HDAC1 (0.76) HDAC1MEN1KMT2AHDAC8HDAC3
SCHEMBL5020756 0.84 HDAC1 (0.76) HDAC1HDAC8HDAC3HDAC11HDAC6
SCHEMBL25198949 0.83 HDAC1 (0.69) HDAC1MAPTMEN1ALDH1A1KMT2A
SCHEMBL5020774 0.82 HDAC1 (0.77) HDAC1HDAC8HDAC3HDAC11HDAC6
SCHEMBL5020761 0.82 HDAC1 (0.79) HDAC1ALDH1A1HDAC8HDAC3HDAC11
SCHEMBL11395099 0.81 CYP1A2 (0.75) HDAC1MAPTMEN1ALDH1A1KMT2A
SCHEMBL798102 0.81 CYP1A2 (0.75) HDAC1MAPTMEN1ALDH1A1KMT2A
SCHEMBL812679 0.81 ALDH1A1 (0.83) HDAC1MAPTMEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE43343-E1 Inhibitors of histone deacetylase METHYLGENE INC. (CA) 2012-05-01 US disclosed