⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9253989 | 0.97 | EPHX1 (0.43) | — | |
| SCHEMBL5117 | 0.97 | EPHX1 (0.43) | — | |
| SCHEMBL3032405 | 0.97 | EPHX1 (0.43) | — | |
| SCHEMBL5708 | 0.97 | EPHX1 (0.43) | — | |
| SCHEMBL9979182 | 0.97 | EPHX1 (0.43) | — | |
| SCHEMBL95966 | 0.97 | EPHX1 (0.43) | — | |
| SCHEMBL5688 | 0.94 | — | — | |
| SCHEMBL349125 | 0.87 | — | — | |
| SCHEMBL28824158 | 0.80 | TSHR (0.39) | — | |
| SCHEMBL10406497 | 0.77 | SHBG (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837490-B | Pyrimido [4, 5-b ] quinoline-4, 5(3H, 10H) -diones as nonsense mutation suppressors | 诺华股份有限公司 | 2017-10-03 | — | — | CN | claimed |
| CN-109642065-B | Rigid propylene compositions with good dimensional stability and excellent surface appearance | 博里利斯股份公司 | 2021-07-27 | — | — | CN | disclosed |
| CN-108137886-B | Long chain branched polypropylene compositions with increased melt strength stability | 博里利斯股份公司 | 2021-05-04 | — | — | CN | disclosed |
| EP-2785695-B1 | NEW BICYCLIC DIHYDROISOQUINOLINE-1-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2020-06-17 | — | — | EP | disclosed |
| EP-3653618-A1 | NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2020-05-20 | — | — | EP | disclosed |
| EP-2755963-B1 | NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2019-10-30 | — | — | EP | disclosed |
| EP-3215505-B1 | PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE | Bayer Pharma AG (DE) | 2019-07-24 | — | — | EP | disclosed |
| US-10118930-B2 | Piperidinylpyrazolopyrimidinones and their use | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-11-06 | — | — | US | disclosed |
| EP-2758388-B1 | NEW BICYCLIC DIHYDROQUINOLINE-2-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2018-02-21 | — | — | EP | disclosed |
| CN-107569487-A | Pyrimido [4,5 b] quinoline 4,5 (3H, 10H) diketone as nonsense mutation repressor | 诺华股份有限公司 | 2018-01-12 | — | — | CN | disclosed |
| US-5086071-A | Improved chemical stability and ppotent in vivo | TORAY INDUSTRIES, INC. (JP) | 1992-02-04 | — | — | US | disclosed |
| EP-0232776-B1 | 2,5,6,7-TETRANOR-4,8-INTER-M-PHENYLENE PGI2 DERIVATIVES | TORAY INDUSTRIES, INC. (JP) | 1990-10-24 | — | — | EP | disclosed |
| EP-0389162-A1 | 2,5,6,7-Tetranor-4,8-inter-m-phenylene PGI2 derivatives | TORAY INDUSTRIES, INC. (JP) | 1990-09-26 | — | — | EP | disclosed |
| US-4935426-A | FUNGICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1990-06-19 | — | — | US | disclosed |
| EP-0365678-A1 | 2,5,6,7-TETRANOR-4,8-INTER-m-PHENYLENE PGI 2 DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1990-05-02 | — | — | EP | disclosed |
| US-4880939-A | ANTISECRETORY AGENTS, HYPOTENSIVES, ANTICOAGULANTS | TORAY INDUSTRIES (JP) | 1989-11-14 | — | — | US | disclosed |
| US-4775692-A | ANTILIPEMIC, ANTICOAGULANT, HYPOTENSIVE, ANTISECRETORY AND ANTIULCER AGENT | TORAY INDUSTRIES, INC. (JP) | 1988-10-04 | — | — | US | disclosed |
| EP-0274064-A2 | 2,5,6,7-Tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene PGI2 derivatives | TORAY INDUSTRIES, INC. (JP) | 1988-07-13 | — | — | EP | disclosed |
| EP-0232776-A2 | 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 derivatives | TORAY INDUSTRIES, INC. (JP) | 1987-08-19 | — | — | EP | disclosed |
| US-4569942-A | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | PFIZER INC. (US) | 1986-02-11 | — | — | US | disclosed |