Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5022005 | 0.80 | MME (0.37) | TSHRKDM4ESMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL5022003 | 0.77 | HDAC3 (0.33) | — | |
| SCHEMBL106091 | 0.71 | TSHR (0.41) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL8089816 | 0.71 | TSHR (0.41) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL12629554 | 0.71 | ALDH1A1 (0.36) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL8098922 | 0.71 | TSHR (0.41) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL21017432 | 0.71 | KDM4E (0.43) | TSHRKDM4ESMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL873013 | 0.69 | TSHR (0.42) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL7826276 | 0.69 | TET2 (0.52) | EPHX2TSHRHSD17B10NLRP3CYP1A2 | |
| SCHEMBL27901303 | 0.69 | TET2 (0.52) | EPHX2TSHRHSD17B10NLRP3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178577-B2 | Tricyclic derivatives as potent and selective histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-05-15 | — | — | US | disclosed |
| US-20090292001-A1 | TRICYCLIC DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090292001-A1 | TRICYCLIC DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC10 | EPHX2 2653/4885TSHR 3975/4885HSD17B10 295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.