Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | BAX | Q07812 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | RAD52 | P43351 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.49 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL605725 | 1.00 | MAPK1 (0.72) | MAPK1LMNAHTTBAXMAPT | |
| SCHEMBL605724 | 1.00 | MAPK1 (0.72) | MAPK1LMNAHTTBAXMAPT | |
| SCHEMBL607384 | 0.95 | LMNA (0.82) | MAPK1LMNAHTTBAXMAPT | |
| SCHEMBL5085817 | 0.87 | IGF1R (0.60) | MAPK1LMNAHTTBAXMAPT | |
| SCHEMBL608481 | 0.86 | BAX (0.61) | MAPK1LMNAHTTBAXMAPT | |
| SCHEMBL605834 | 0.85 | BAX (0.63) | MAPK1LMNAHTTBAXMAPT | |
| SCHEMBL605835 | 0.85 | BAX (0.63) | MAPK1LMNAHTTBAXMAPT | |
| SCHEMBL5022852 | 0.85 | BAX (0.63) | MAPK1LMNAHTTBAXMAPT | |
| SCHEMBL607023 | 0.85 | LMNA (0.73) | MAPK1LMNAHTTBAXMAPT | |
| SCHEMBL607474 | 0.84 | LMNA (1.00) | MAPK1LMNAHTTMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-B1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | SERONO LAB (CH) | 2008-06-04 | — | — | EP | claimed |
| US-8410110-B2 | 9-(piperazinylalkyl) carbazoles as Bax-modulators | MERCK SERONO SA (CH) | 2013-04-02 | — | — | US | disclosed |
| EP-1237887-B1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | SERONO LAB (CH) | 2008-06-04 | — | — | EP | disclosed |