Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAX | Q07812 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | RAD52 | P43351 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | PER2 | O15055 | 1/20 | 0.47 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL605835 | 1.00 | BAX (0.63) | BAXMAPK1MAPTTP53CYP3A4 | |
| SCHEMBL605834 | 1.00 | BAX (0.63) | BAXMAPK1MAPTTP53CYP3A4 | |
| SCHEMBL607210 | 0.95 | MEN1 (0.69) | BAXMAPK1MAPTTP53CYP3A4 | |
| SCHEMBL607023 | 0.88 | LMNA (0.73) | BAXMAPK1MAPTTP53CYP3A4 | |
| SCHEMBL610266 | 0.88 | BAX (0.60) | BAXMAPK1MAPTTP53CYP3A4 | |
| SCHEMBL607747 | 0.86 | BAX (0.61) | BAXMAPK1MAPTTP53CYP3A4 | |
| SCHEMBL608481 | 0.86 | BAX (0.61) | BAXMAPK1MAPTTP53CYP3A4 | |
| SCHEMBL6819686 | 0.86 | BAX (0.82) | BAXMAPK1MAPTTP53CYP3A4 | |
| SCHEMBL5026887 | 0.86 | BAX (0.63) | BAXMAPK1MAPTTP53CYP3A4 | |
| SCHEMBL5022683 | 0.85 | MAPK1 (0.72) | BAXMAPK1MAPTTP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-B1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | SERONO LAB (CH) | 2008-06-04 | — | — | EP | claimed |
| EP-1094063-A1 | 9-(Piperazinylalkyl)carbazoles as Bax-modulators | Applied Research Systems ARS Holding N.V. (AN) | 2001-04-25 | — | — | EP | claimed |
| US-8410110-B2 | 9-(piperazinylalkyl) carbazoles as Bax-modulators | MERCK SERONO SA (CH) | 2013-04-02 | — | — | US | disclosed |
| EP-1237887-B1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | SERONO LAB (CH) | 2008-06-04 | — | — | EP | disclosed |
| EP-1094063-A1 | 9-(Piperazinylalkyl)carbazoles as Bax-modulators | Applied Research Systems ARS Holding N.V. (AN) | 2001-04-25 | — | — | EP | disclosed |