Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15628980 | 0.82 | ALDH1A1 (0.50) | ALDH1A1GAAHPGDMEN1MAPT | |
| SCHEMBL15625437 | 0.82 | ALDH1A1 (0.34) | ALDH1A1GAAHPGDMEN1MAPT | |
| SCHEMBL12428932 | 0.76 | HSD17B10 (0.46) | ALDH1A1GAAHPGDMEN1MAPT | |
| SCHEMBL14492579 | 0.75 | ALDH1A1 (0.34) | ALDH1A1GAAHPGDMEN1MAPT | |
| SCHEMBL26700013 | 0.73 | TNKS (0.38) | ALDH1A1GAAHPGDMEN1MAPT | |
| SCHEMBL24405342 | 0.72 | HSD17B10 (0.50) | ALDH1A1GAAHPGDMEN1MAPT | |
| SCHEMBL8738948 | 0.71 | ALDH1A1 (0.55) | ALDH1A1GAAHPGDMEN1MAPT | |
| SCHEMBL13252969 | 0.71 | ALDH1A1 (0.44) | ALDH1A1GAAHPGDMEN1MAPT | |
| SCHEMBL25897067 | 0.71 | AR (0.39) | ALDH1A1GAAHPGDMEN1MAPT | |
| SCHEMBL16687894 | 0.70 | AR (0.41) | ALDH1A1GAAHPGDMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064744-A2 | TETRAHYDROQUINOLINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORϒ ACTIVITY AND THE TREATMENT OF DISEASE | LYCERA CORPORATION (US) | 2012-05-18 | — | — | WO | disclosed |