Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24405342 | 0.93 | HSD17B10 (0.50) | HSD17B10ALDH1A1GAAHPGDMEN1 | |
| SCHEMBL15628980 | 0.85 | ALDH1A1 (0.50) | HSD17B10ALDH1A1GAAHPGDMEN1 | |
| SCHEMBL30896337 | 0.84 | ALDH1A1 (0.44) | HSD17B10ALDH1A1GAAHPGDMEN1 | |
| SCHEMBL5023388 | 0.76 | ALDH1A1 (0.43) | HSD17B10ALDH1A1GAAHPGDMEN1 | |
| SCHEMBL22476657 | 0.75 | ALDH1A1 (0.42) | HSD17B10ALDH1A1GAAHPGDMEN1 | |
| SCHEMBL25558931 | 0.74 | HSD17B10 (0.45) | HSD17B10 | |
| SCHEMBL520908 | 0.73 | BRD4 (0.51) | ALDH1A1GAAHPGDMEN1MAPT | |
| SCHEMBL1453685 | 0.73 | ALDH1A1 (0.58) | HSD17B10ALDH1A1GAAHPGDMEN1 | |
| SCHEMBL30464716 | 0.73 | ALDH1A1 (0.58) | HSD17B10ALDH1A1GAAHPGDMEN1 | |
| SCHEMBL16687894 | 0.72 | AR (0.41) | HSD17B10ALDH1A1GAAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981903-B2 | 2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer | GLAXOSMITHKLINE LLC (US) | 2011-07-19 | — | — | US | disclosed |