Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | CASP3 | P42574 | 1/20 | 0.68 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.68 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.68 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8076003 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL28488116 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| Hydrochloric Acid SCHEMBL28640787 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL12351738 | 0.81 | RAB9A (1.00) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL10697633 | 0.81 | RAB9A (0.69) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL5016960 | 0.76 | MAPT (0.51) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL11727782 | 0.76 | TSHR (0.49) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL21753481 | 0.75 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL5016950 | 0.75 | SMN1; SMN2 (0.45) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL16484012 | 0.74 | NPC1 (0.51) | SMN1; SMN2RAB9ALMNANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638556-B1 | 2-AMINOBENZOTHIAZOLES AS CB1 RECEPTOR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-04-02 | — | — | EP | disclosed |