Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 12/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MGLL | Q99685 | 1/20 | 0.55 |
| ▸ | UBE2M | P61081 | 1/20 | 0.52 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5022987 | 0.90 | F10 (0.76) | F10L3MBTL1MGLLLMNAHPGD | |
| SCHEMBL5022242 | 0.88 | F10 (0.77) | F10L3MBTL1MGLLLMNAHPGD | |
| SCHEMBL5023535 | 0.88 | F10 (0.73) | F10L3MBTL1MGLLLMNAHPGD | |
| SCHEMBL5022491 | 0.88 | F10 (0.76) | F10L3MBTL1MGLLLMNAHPGD | |
| SCHEMBL5026710 | 0.86 | F10 (1.00) | F10L3MBTL1MGLLLMNAHPGD | |
| SCHEMBL5023423 | 0.86 | F10 (0.73) | F10L3MBTL1MGLLLMNAHPGD | |
| SCHEMBL4445858 | 0.80 | F10 (0.69) | F10L3MBTL1LMNAALDH1A1POLB | |
| SCHEMBL4451338 | 0.73 | F10 (0.63) | F10L3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL4442251 | 0.73 | F10 (1.00) | F10 | |
| SCHEMBL4443718 | 0.72 | F10 (0.94) | F10L3MBTL1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732918-B1 | NOVEL PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-11-12 | — | — | EP | disclosed |
| EP-1732918-A1 | NOVEL PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092881-A1 | NOVEL PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-06 | — | — | WO | disclosed |