Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 8/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | PHGDH | O43175 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5023474 | 0.90 | F10 (0.76) | F10POLBEPHX2LMNAL3MBTL1 | |
| SCHEMBL5022242 | 0.88 | F10 (0.77) | F10POLBEPHX2LMNAL3MBTL1 | |
| SCHEMBL5022491 | 0.88 | F10 (0.76) | F10POLBLMNAL3MBTL1HPGD | |
| SCHEMBL5026710 | 0.86 | F10 (1.00) | F10POLBLMNAL3MBTL1HPGD | |
| SCHEMBL5023535 | 0.86 | F10 (0.73) | F10POLBLMNAL3MBTL1HPGD | |
| SCHEMBL5023423 | 0.86 | F10 (0.73) | F10POLBLMNAL3MBTL1HPGD | |
| SCHEMBL4445858 | 0.80 | F10 (0.69) | F10POLBLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL4451338 | 0.79 | F10 (0.63) | F10LMNAL3MBTL1NPC1MAPT | |
| SCHEMBL5026695 | 0.79 | LMNA (0.63) | F10POLBEPHX2LMNANPC1 | |
| SCHEMBL4442251 | 0.79 | F10 (1.00) | F10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732918-B1 | NOVEL PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-11-12 | — | — | EP | disclosed |
| EP-1732918-A1 | NOVEL PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092881-A1 | NOVEL PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-06 | — | — | WO | disclosed |