⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12269430 | 0.69 | GSK3A (0.40) | — | |
| SCHEMBL11455675 | 0.64 | RGS4 (1.00) | — | |
| SCHEMBL14941895 | 0.63 | RGS4 (0.70) | — | |
| SCHEMBL3384007 | 0.63 | GSK3B (1.00) | — | |
| SCHEMBL141994 | 0.61 | GSK3A (0.44) | — | |
| SCHEMBL21497507 | 0.60 | — | — | |
| SCHEMBL12360450 | 0.56 | GSK3A (0.39) | — | |
| SCHEMBL14700971 | 0.55 | HTT (0.42) | — | |
| SCHEMBL13024710 | 0.54 | ATAD2 (0.39) | — | |
| SCHEMBL12948673 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4183816-A | LUBRICANTS AND HYDRAULIC FLUIDS | OLIN CORPORATION (US) | 1980-01-15 | — | — | US | claimed |
| US-20170000772-A1 | SMALL MOLECULE MODULATORS OF PRB INACTIVATION | WISTAR INST (US) | 2017-01-05 | — | — | US | disclosed |
| US-9469618-B2 | Thiadiazolidinediones as GSK-3 inhibitors | ASD THERAPEUTICS PARTNERS, LLC (US) | 2016-10-18 | — | — | US | disclosed |
| US-9447060-B2 | Small molecule modulators of pRb inactivation | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2016-09-20 | — | — | US | disclosed |
| US-20160257660-A1 | THIADIAZOLIDINEDIONES AS GSK-3 INHIBITORS | ASD THERAPEUTICS PARTNERS LLC (US) | 2016-09-08 | — | — | US | disclosed |
| US-9371299-B2 | Thiadiazolidinediones as GSK-3 inhibitors | ASD THERAPEUTICS PARTNERS, LLC (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150038538-A1 | THIADIAZOLIDINEDIONES AS GSK-3 INHIBITORS | ASD THERAPEUTICS PARTNERS LLC (US) | 2015-02-05 | — | — | US | disclosed |
| US-20140323442-A1 | Small Molecule Modulators of pRb Inactivation | WISTAR INST (US) | 2014-10-30 | — | — | US | disclosed |
| US-8865750-B2 | Small molecule inhibitors of RGS proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-10-21 | — | — | US | disclosed |
| US-20120277273-A1 | SMALL MOLECULE INHIBITORS OF RGS PROTEINS | THE UNIVERSITY OF BATH (GB) | 2012-11-01 | — | — | US | disclosed |
| WO-2012065065-A9 | METHODS AND COMPOSITIONS FOR MODULATING HAIR GROWTH, WOUND HEALING AND SCAR REVISION | FOLLICA, INC. (US) | 2012-10-11 | — | — | WO | disclosed |
| WO-2012065065-A1 | METHODS AND COMPOSITIONS FOR MODULATING HAIR GROWTH, WOUND HEALING AND SCAR REVISION | FOLLICA, INC. (US) | 2012-05-18 | — | — | WO | disclosed |
| US-4183816-A | LUBRICANTS AND HYDRAULIC FLUIDS | OLIN CORPORATION (US) | 1980-01-15 | — | — | US | disclosed |