Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.44 |
| ▸ | PLAT | P00750 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29850012 | 0.70 | FEN1 (0.37) | HRH4 | |
| SCHEMBL21138823 | 0.68 | ADRB2 (0.56) | HTR2CAPPHTR1ASLC6A2SLC6A4 | |
| SCHEMBL22776499 | 0.67 | IKBKB (0.42) | HTR2CHRH4IKBKBRPS6KA3KMT2A | |
| SCHEMBL18081223 | 0.67 | IKBKB (0.65) | IKBKB | |
| SCHEMBL16845857 | 0.67 | KMT2A (0.56) | HTR2CPLATMEN1POLBKMT2A | |
| SCHEMBL30541520 | 0.67 | HTR2C (0.41) | HTR2CHRH4IKBKBHTR1ASLC6A2 | |
| SCHEMBL17450033 | 0.67 | HTR2C (0.56) | HTR2CPTPN5MEN1POLBKMT2A | |
| SCHEMBL14321224 | 0.67 | HTR2C (0.61) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL18038833 | 0.66 | IKBKB (0.64) | IKBKB | |
| Hydrochloric Acid SCHEMBL18038706 | 0.66 | IKBKB (0.64) | IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943242-A1 | PIPERIDIN-4-YL-PYRIDAZIN-3-YLAMINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007048779-A1 | PIPERIDIN-4-YL-PYRIDAZIN-3-YLAMINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-03 | — | — | WO | disclosed |