Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 3/20 | 0.57 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PER2 | O15055 | 2/20 | 0.46 |
| ▸ | CRY1 | Q16526 | 2/20 | 0.46 |
| ▸ | CRY2 | Q49AN0 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | BAX | Q07812 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL608488 | 0.79 | RAD52 (0.66) | RAD52NLRP1MEN1KMT2APOLB | |
| SCHEMBL6816191 | 0.79 | RAD52 (0.76) | RAD52NLRP1MEN1KMT2APOLB | |
| SCHEMBL6819364 | 0.79 | RAD52 (0.76) | RAD52NLRP1MEN1KMT2APOLB | |
| SCHEMBL606776 | 0.76 | RAD52 (0.57) | RAD52NLRP1MEN1KMT2APOLB | |
| SCHEMBL607341 | 0.74 | RAD52 (0.76) | RAD52NLRP1MEN1KMT2APOLB | |
| SCHEMBL1306615 | 0.74 | MEN1 (0.70) | RAD52NLRP1MEN1KMT2APOLB | |
| SCHEMBL607619 | 0.73 | LMNA (0.81) | RAD52NLRP1MEN1KMT2APOLB | |
| SCHEMBL28916672 | 0.73 | RAD52 (0.70) | RAD52NLRP1MEN1KMT2AKDM4E | |
| SCHEMBL608989 | 0.73 | RAD52 (0.73) | RAD52NLRP1MEN1KMT2APOLB | |
| SCHEMBL6823233 | 0.73 | RAD52 (0.86) | RAD52NLRP1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-B1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | SERONO LAB (CH) | 2008-06-04 | — | — | EP | claimed |
| US-8410110-B2 | 9-(piperazinylalkyl) carbazoles as Bax-modulators | MERCK SERONO SA (CH) | 2013-04-02 | — | — | US | disclosed |
| EP-1237887-B1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | SERONO LAB (CH) | 2008-06-04 | — | — | EP | disclosed |