Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 4/20 | 0.42 |
| ▸ | STS | P08842 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5028348 | 1.00 | LMNA (0.49) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL6464944 | 0.87 | LMNA (0.44) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL7887224 | 0.87 | LMNA (0.44) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL6461945 | 0.87 | LMNA (0.44) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL6466887 | 0.87 | LMNA (0.44) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL14421698 | 0.83 | HSD17B1 (0.67) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL12364241 | 0.83 | HSD17B1 (0.67) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL2244884 | 0.83 | HSD17B1 (0.67) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL5024255 | 0.83 | HSD17B1 (0.67) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL6535977 | 0.83 | HSD17B1 (0.67) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427748-B1 | 17ALPHA-HYDROXY-14BETA-STEROIDS WITH HORMONAL EFFECT | ORGANON NV (NL) | 2008-05-14 | — | — | EP | disclosed |
| US-7169769-B2 | 17α-hydroxy-14β-steroids with hormonal effect | AKZO NOBEL N.V. (NL) | 2007-01-30 | — | — | US | disclosed |
| US-6881728-B1 | 14-β, 17-α-hydroxymethylandrostane derivatives as androgens | AKZO NOBEL N.V. (NL) | 2005-04-19 | — | — | US | disclosed |
| US-20040259849-A1 | 17Alpha-hydroxy-14Beta-steroids with hormonal effect | MERCK SHARP & DOHME B.V. (NL) | 2004-12-23 | — | — | US | disclosed |
| EP-1163259-B1 | 14.BETA.,17-ALPHA-HYDROXYMETHYLANDROSTANE DERIVATIVES AS ANDROGENS | AKZO NOBEL NV (NL) | 2002-11-20 | — | — | EP | disclosed |
| EP-1163259-A1 | 14.BETA.,17-ALPHA-HYDROXYMETHYLANDROSTANE DERIVATIVES AS ANDROGENS | Akzo Nobel N.V. (NL) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000053619-A1 | 14.BETA., 17-ALPHA-HYDROXYMETHYLANDROSTANE DERIVATIVES AS ANDROGENS | AKZO NOBEL N.V. (NL) | 2000-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259849-A1 | 17Alpha-hydroxy-14Beta-steroids with hormonal effect | CYP17A1, HSD17B11, NR5A1 | LMNA 2554/4885HSD17B1 13/4885MAPT 4506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.