Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 12/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6038256 | 0.89 | ADORA2A (0.55) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL6038267 | 0.86 | ADORA2A (0.57) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL5604411 | 0.84 | ADORA2A (0.64) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL27661596 | 0.83 | ADORA2A (0.58) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL5024971 | 0.79 | ADORA2A (0.55) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL5022322 | 0.79 | ADORA2A (0.53) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL5016100 | 0.78 | ADORA2A (0.51) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL27681229 | 0.77 | ADORA2A (0.53) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL5016138 | 0.77 | ADORA2A (0.52) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL6038275 | 0.77 | ADORA2A (0.64) | ADORA2AADORA1ADORA3ADORA2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058356-A1 | 2,6 Bisheteroaryl-4-Aminopyrimidines as Adenosine Receptor Antagonists | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058356-A1 | 2,6 Bisheteroaryl-4-Aminopyrimidines as Adenosine Receptor Antagonists | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA1 3/4885ADORA3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.