Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.57 |
| ▸ | NOS1 | P29475 | 3/20 | 0.57 |
| ▸ | NOS2 | P35228 | 3/20 | 0.57 |
| ▸ | SLC7A5 | Q01650 | 8/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.53 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | XIAP | P98170 | 1/20 | 0.53 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729253 | 1.00 | NOS3 (0.57) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL28655647 | 0.92 | NOS3 (0.55) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL28655648 | 0.92 | NOS3 (0.55) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL17142343 | 0.86 | NOS3 (0.57) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL7279140 | 0.83 | NOS3 (0.64) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL7279148 | 0.83 | NOS3 (0.64) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL2778381 | 0.83 | NOS3 (0.64) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL10419779 | 0.83 | NOS3 (0.60) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL2778383 | 0.83 | NOS3 (0.64) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL2729020 | 0.82 | HIF1A (0.56) | SLC7A5PTGS1ALPIPKMXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058325-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATMENT OF DISEASES MEDIATED BY HIF-1 | ONCOTHYREON INC. (US) | 2012-05-03 | — | — | WO | disclosed |
| WO-2011057220-A2 | COMPOSITIONS AND METHODS FOR TREATING LYMPHOMA | NORTHWESTERN UNIVERSITY (US) | 2011-05-12 | — | — | WO | disclosed |